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The PROPHY-VAP Trial: Ceftriaxone to Prevent VAP in Patients with Acute Brain Injury

REBEL EM

1, 2 Its occurrence often portends worse outcomes in intubated patients, whose projected hospital course was already tenuous. PMID: 38262428 Clinical Question: Does antibiotic prophylaxis with a single dose of ceftriaxone reduce the incidence of early VAP in adults with severe brain injury who require mechanical ventilation?

Hospital 124
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The RAMPP Trial: Randomised Ambulatory Management of Primary Pneumothorax

REBEL EM

However, management continues to be debated and may lead to unnecessary hospitalization. PMID: 32622394 Clinical Question: Can ambulatory management of patients with primary spontaneous pneumothorax reduce the length of hospitalization? Often patients are otherwise young and healthy. Paper: Hallifax RJ et al.

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Cetirizine Vs Diphenhydramine For the Treatment of Acute Urticaria in the ED

REBEL EM

Clinical Question: Is IV cetirizine noninferior to IV diphenhydramine for the treatment of acute urticaria? PMID: 32653333 What They Did Multi-center, double-blind, randomized, phase 3 clinical trial with a parallel-group, active-controlled, non-inferiority design. Article: Abella BS et al. Ann Emerg Med 2020.

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REBEL Core Cast 122.0 – Neutropenic Fever

REBEL EM

Follow your hospital’s protocol (if available). High Risk Patients will need hospitalization and IV antibiotics. Neutropenic Fever: Fever (one reading of 38.3C This will have been formulated based on local resistance patterns and likely with input from your institution’s oncologists.

Disease 104