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PET links depressive symptoms to Alzheimer’s brain pathology

AuntMinnie

Columbia University researchers in New York City have reported that worsening depression in older adults is related to higher levels of Alzheimers disease pathology, specifically the accumulation of tau protein. The study was published April 9 in the American Journal of Geriatric Psychiatry. The full study can be found here.

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PET reveals patient responses to new Alzheimer’s disease drug

AuntMinnie

Patients with less tau pathology on PET scans may respond better to treatment with the new Alzheimer’s disease drug donanemab, according to an October 25 news report in the journal Practical Neurology. Food and Drug Administration, with a decision expected by the end of 2023. The full report is available here.

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Metabolic MRI technique shows promise in Alzheimer’s patients

AuntMinnie

Deuterium metabolic imaging (DMI) was highly aligned with F-18 FDG-PET -- a cornerstone of dementia diagnostics -- in patients with Alzheimer's disease in a study published April 8 in Radiology. Given that PET scans are more expensive and expose patients to small amounts of radiation, DMI is being explored as an alternative.

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Evidence grows for use of amyloid PET in China

AuntMinnie

Chinese clinicians have provided evidence in a “real-world study” that shows amyloid PET imaging is effective for diagnosing and managing patients with Alzheimer’s disease, according to a study published February 8 in Alzheimer’s and Dementia. of patients, noted lead author Ke-Liang Chen, MD, a neurologist at Fudan University. “In

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Midlife belly fat linked to increased Alzheimer's risk

AuntMinnie

People with higher amounts of visceral abdominal fat in midlife may be at increased risk of Alzheimer's disease, according to research to be presented at the upcoming RSNA meeting. A subset of 32 patients underwent PET imaging to identify any amyloid plaque and tau tangles that would indicate the development of Alzheimer's disease.

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FAPI-PET shows promise in patients with lung cancer

AuntMinnie

A group at University Hospital Heidelberg in Germany assessed the approach in 19 patients referred by their treating physicians because of inconclusive lung cancer findings on CT and F-18 FDG-PET. FAPI-PET either confirmed or ruled out the disease in all cases, the group found.

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Research Spotlight: Validating an MRI Biomarker for Early Onset Alzheimer’s Disease

Imaging Technology

Is there a signature biomarker for younger/early-onset Alzheimer’s Disease (EOAD)? Sporadic early-onset Alzheimer’s disease (EOAD) is rare and understudied. The Sporadic Early-onset Alzheimer’s Disease Signature Of Atrophy: Preliminary Findings From The Longitudinal Early-onset Alzheimer’s Disease Study (LEADS) Cohort.

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