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This may be due to inhibition of the MEK-MAPK pathway during DNA damage response, resulting in radiosensitization of cancer cells to 177Lu-rhPSMA-10.1. Our ongoing Phase 1/2 clinical trial ( NCT05413850 ) is evaluating 177Lu-rhPSMA-10.1 Radiohybrid technology and rhPSMA originated from the Technical University of Munich , Germany.
The balance of dose and image quality is even more important in pediatric medical imaging. Not only are children more radiosensitive than adults (the cancer risk per unit dose of ionizing radiation is higher), but children also have a longer expected lifetime, which puts them at greater risk of cancer following radiation exposure.(1)
Since children are more radiosensitive and prone to the negative repercussions of radiation than adults, technical factors should be modified to limit radiation to ONLY what’s necessary for diagnosis. This will provide a diagnosticimage with roughly half the radiation dose but with little degradation of the image quality.
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