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PET visualizes acute graft versus host disease

AuntMinnie

F-18 fluorothymidine (FLT) PET can identify early acute gastrointestinal graft versus host disease (GVHD) after patients undergo bone marrow transplants, according to a study published December 13 in Radiology: Imaging Cancer. Blood cancers start in the cells of the immune system or in blood-forming tissue, such as the bone marrow.

Disease 279
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DL algorithm targeting prostate cancer demonstrates clinical impact

AuntMinnie

When radiologists interpretations are indeterminate, a commercially available deep learning algorithm could find clinically significant prostate cancer with improved specificity while maintaining sensitivity, suggested research published March 11 in Radiology. A majority (179) of participants underwent multiparametric MRI, the authors noted.

Clinic 230
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MRI radiomics model predicts risk in women with DCIS

AuntMinnie

The study highlights how radiomics can help stratify risk in DCIS cases compared with clinical and qualitative imaging information alone, noted lead authors Kalina Slavkova, PhD, of Columbia University in New York City, and Ruya Kang, PhD, of Brown University in Providence, RI. About 20% of new breast cancers in the U.S.

MRI 297
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PET links depressive symptoms to Alzheimer’s brain pathology

AuntMinnie

Columbia University researchers in New York City have reported that worsening depression in older adults is related to higher levels of Alzheimers disease pathology, specifically the accumulation of tau protein. The study was published April 9 in the American Journal of Geriatric Psychiatry. The full study can be found here.

PET Scan 215
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Clinical practice LCS program finds more disease than NLST

AuntMinnie

Over a five-year period, a clinical practice lung cancer screening program at Duke University Medical Center in Durham, NC, found more disease than did the National Lung Screening Trial (NLST), researchers have reported. It also found more stage IV disease, wrote a team led by Kyle Lafata, PhD. “As versus 2.4%. Specificity 83.8%

Disease 209
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ECR: PET/MRI highly effective for detecting prostate cancer

AuntMinnie

The finding is from a preliminary analysis of 23 patients enrolled in an ongoing clinical trial, noted Giorgio Brembilla, MD, PhD, of the IRCCS San Raffaele Scientific Institute in Milan, Italy. The trial will eventually enroll 167 undiagnosed patients with suspected disease who have been referred for biopsies, Brembilla noted.

MRI 260
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PET reveals patient responses to new Alzheimer’s disease drug

AuntMinnie

Patients with less tau pathology on PET scans may respond better to treatment with the new Alzheimer’s disease drug donanemab, according to an October 25 news report in the journal Practical Neurology. Research suggests that the accumulation of these proteins is a continuous process that starts decades before the onset of symptoms.

Disease 298