CRYOSTAT-2: Early Empiric Cryoprecipitate in Major Trauma
REBEL EM
OCTOBER 30, 2023
Background: Hemorrhage is the leading cause of trauma related mortality. The initial injury is often complicated by multifactorial coagulopathy that can exacerbate bleeding. Fibrinogen is the precursor to fibrin and a major component of stable clot formation. Fibrinogen and fibrin are often depleted during major trauma as a result of consumption, breakdown, and dilution.
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